America has always "tolerated" separatism be it native Americans, the Amish, Shakers, and Hasidic Jews, etc. However, tolerating groups who simply ask to be left alone has not been the problem. The problem is when separatists' groups want our government to use public education combined with institutional and system racism to promote separatism.

As long as the vast majority of Americans believe in integration, tolerance, and individual rights and we promote those values in our educational system, we will be able to handle groups that opt not to integrate as long as the decision not to integrate is a personal one made by each individual within the separatist group.

However, any separatist group that tries to prevent its members from their own individual pursuit of happiness cannot be allowed to impose themselves on members who chose to leave the group. Separatism must always be voluntary.

Native Americans while having a unique history are not particularly unique as far as being a group that attempts to maintain their separate identity. With regard to the "border wall", the Supreme Court has argued that accommodation is required where possible... so it sounds like the government would be compelled to work with Tohono O'odham Nation to achieve the goal of border security some other way if possible. Given an unemployment rate of over 60% and with 41% of the population living in poverty, perhaps the federal government and Tohono O'odham nation could agree to employ members of the tribe as border agents with incentives to keep the border secure.